Linda Klavinskis

Professor
Linda
Klavinskis

Professor
King's College London
Biography

Linda S Klavinskis, PhD, FRCPath, is a viral immunologist and past Vice-Dean of Postgraduate Research, Faculty of Life Sciences & Medicine at the King’s College, London, UK. She received her doctorate from the University of London studying the pathogenic mechanisms underlying the autoimmune disease Myasthenia gravis. As a Fulbright Fellow, her postdoctoral training in viral pathogenesis focused on CD8 T-cell immunity and virus control in Professor Michael Oldstone’s laboratory at The Scripps Research Institute, La Jolla, USA. Following a brief period at Roche, she joined the faculty at King’s College London, UK, where her research has focused on how the innate immune system regulates adaptive immune responses to pathogens, and uses this knowledge in the design of vaccines and adjuvants. This has included enhancing mucosal immunity against HIV/SIV, methods to deliver DNA vaccines, deciphering an alternative mode of antigen presentation termed ‘cross-dressing’, and unravelling mechanisms that contribute to epitope selection and CD8 T-cell immunodominance. She has also engaged in translational research that has pursued the development of effective adjuvants for human vaccines, and developing vaccines that provide protection against viruses that infect mucosal surfaces. More recently, her work has been influential in the development of microneedle delivery systems for skin immunization. Dr. Klavinskis has co-authored over 100 peer-reviewed publications, and holds several patents. She is a Fellow of the Royal College of Pathologists, a 2017 International Society for Vaccines Fellow and is a past President of the London based Medical Research Club, a distinguished scientific society, established in 1891.

Research interests

My current research interests address the cellular immune response to virus infection and vaccination with a focus on developing effective vaccines against HIV, influenza A virus and emerging viral diseases. This includes: (1) understanding how virus proteins are processed and presented to generate effective anti-viral T cells, (2) how viruses subvert these steps to evade or narrow the breadth of the T cell responses, (3) the role of innate cells in recruiting CD8+T cells to epithelial barrier tissues as a correlate of protective immunity and (4) development of ‘needle-free’ delivery systems for vaccines using dissolvable ‘microneedle arrays’ fabricated to contain thermostabilised vaccine within the needle matrix for vaccine delivery to skin