Karina Pasquevich

Karina
Pasquevich

Researcher
University of San Martin
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Biography
My name is Karina Pasquevich, and I am an Argentinian scientist, born in La Plata on June 13, 1978. I earned my degree in Biochemistry from the National University of La Plata in 2003 and completed my Ph.D. in Immunology at the University of Buenos Aires in 2009. My doctoral research, under the supervision of Dr. Juliana Cassataro, focused on the development of vaccines for Brucellosis and was carried out at the Institute of Humoral Immunity Research (IDEHU) and the Immunogenetics Laboratory at the Hospital de Clínicas, UBA. Between 2010 and 2011, I worked as a postdoctoral fellow at the University of Tübingen in Germany, with funding from the Alexander von Humboldt Foundation. During that time, I studied bacterial infections and their effects on immune cell development. In 2012, I joined Dr. Cassataro’s group as an assistant researcher at CONICET, and I currently work as an independent researcher at the Institute for Biotechnology Research (IIB-INTECH) at the National University of San Martín. Since the beginning of my scientific career, I have focused on vaccine development, with a particular interest in the design and application of novel vaccine adjuvants. I have published 38 peer-reviewed scientific papers, co-authored two patents on vaccine adjuvants (one granted, one pending), and led three research grants as principal investigator. I have also been actively involved in the development of ARVAC, a recombinant subunit vaccine against COVID-19, which has been approved for human use in Argentina.
Research interests
My research interests lie in the field of immunology, with a strong focus on vaccine development. I am particularly interested in the design, characterization, and application of novel adjuvants, especially mucosal adjuvants, to enhance vaccine efficacy. A key part of my work involves testing these adjuvants in various vaccine formulations and delivery routes to elicit robust and protective immune responses. I am also interested in the immune response to both bacterial and viral infections, as well as the responses induced by vaccination, with a special focus on the effector functions of antibodies.
Projects you're working on
I am currently working on the structure–activity relationship of mucosal vaccine adjuvants, aiming to understand how their molecular features influence immune activation and efficacy. In parallel, I am involved in evaluating the immunogenicity of various vaccine formulations, both in preclinical models and in clinical trial samples, to identify correlates of protection and improve vaccine design.
Discipline
Bacteriology Challenge model development Clinical trials – efficacy Clinical trials – safety Formulation technology Immunology – B-cells Immunology – T-cells Immunology – innate Structural biology
Host species
Cattle Fish Pigs Poultry Small ruminants Zoonoses
Pathogen
Bacteria BacteriaBrucella BacteriaChlamydophila BacteriaClostridia BacteriaE. coli BacteriaLeptospira BacteriaMycobacteria bovis BacteriaSalmonella BacteriaYersinia Parasites Viruses VirusesAdenovirus VirusesAfrican swine fever virus VirusesArboviruses VirusesArteriviruses VirusesAvian papillomavirus VirusesAvian polyomavirus VirusesBluetongue virus VirusesBovine ephemeral fever virus VirusesBovine viral diarrhoea VirusesCapripoxvirus VirusesChicken anaemia virus VirusesClassical swine fever virus VirusesCoronavirus VirusesCytomegalovirus VirusesEbolaviruses/filoviruses VirusesInfluenza virus VirusesNewcastle disease virus VirusesNipah virus VirusesParainfluenza virus VirusesParamyxoviruses VirusesParvovirus VirusesPorcine reproductive and respiratory syndrome virus VirusesPoxviruses VirusesRabies virus VirusesRespiratory syncytial virus VirusesRift Valley fever virus VirusesRotavirus
Stage of vaccine development
Adjuvants Clinical trials Correlates of protection – immunomonitoring Pre-clinical trials Vaccine delivery