Rafaela Flor

Rafaela
Flor

PhD Candidate
Virginia Tech
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Biography
I’m a PhD candidate in Biomedical and Veterinary Sciences at Virginia Tech, within the Virginia-Maryland College of Veterinary Medicine. My research focuses on host-pathogen interactions in hemorrhagic and encephalitic arboviral diseases, particularly Rift Valley fever virus. I’m deeply passionate about uncovering molecular mechanisms to support the development of vaccines and therapeutic strategies targeting critical and neglected zoonotic emerging threats. ———————————————————————————— My journey into virology began during my veterinary medicine degree at Santa Catarina State University in Brazil, where I worked on serological diagnostics and autogenous vaccine development for bovine viruses. A pivotal internship at George Mason University’s Biomedical Research Lab (Manassas, VA, USA) deepened my passion for host-pathogen interactions, giving me hands-on experience in sterile technique, cell culture, and in vitro infections. Now pursuing a PhD in Biomedical and Veterinary Sciences at Virginia Tech, I study protein-protein interactions in hemorrhagic and encephalitic arboviruses—especially Rift Valley fever virus—under Dr. Kylene Kehn-Hall’s mentorship. I am proud to be part of a strong community of scientists at Virginia Tech who embrace the One Health concept, studying the interconnectedness of animals, humans, the environment, and pathogens. Additionally, I am a member of the Center for Emerging, Zoonotic, and Arthropod-borne Pathogens (CeZAP), a collaborative initiative focused on interdisciplinary work addressing the global challenges posed by emerging infectious diseases. I’m always open to connecting with fellow researchers, collaborators, and science enthusiasts. In my free time, I explore the outdoors with my stubborn and sweet Beagle mix, Calvin.
Research interests
My research interests center on neglected tropical zoonoses and their impact on both animal and human health. I am particularly focused on the molecular virology of emerging arboviruses, investigating how viruses like Rift Valley fever virus manipulate host signaling pathways to drive infection and inflammation. Through this work, I aim to contribute to the development of innovative, host-directed strategies that strengthen both public health and veterinary medicine.
Projects you're working on
My current project focuses on Rift Valley fever virus (RVFV), where I study key protein–protein interactions between the virus and host cells. By targeting these interactions, I aim to identify host-directed countermeasures that can both limit infection and reduce harmful inflammation, while also uncovering important mechanistic insights into how the virus operates.
Discipline
Cellular biology Molecular biology Virology
Host species
Buffalo Camels Cattle Small ruminants Zoonoses
Pathogen
Viruses VirusesArboviruses VirusesRift Valley fever virus
Stage of vaccine development
Antigen discovery and immunogen design Pre-clinical trials