Dr
Sofia
Khanum
Dr
Sofia
Khanum
Scientist
Bioeconomy research Institute, AgResearch, Palmerston North, New Zealand
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I am a scientist in the Animal Health Solutions team at AgResearch, New Zealand, where I contribute to the methane vaccine program with a focus on immunological strategies for methane mitigation. My current research involves epitope mapping through peptide design, studying antigen-antibody interactions, and characterizing immunological epitopes of methanogen proteins. I am also developing advanced tools such as flow cytometry and immune-capture technologies to investigate gut microbial communities and their interactions with the host immune system.
My academic background is rooted in microbiology and bacterial pathogenesis. During my PhD, I characterised secretins—large outer membrane channels in Gram-negative bacteria—demonstrating how these structures serve as vulnerable points for antibiotic intervention and how stress responses are essential for bacterial survival during toxin secretion. This work highlighted potential targets for combating antibiotic-resistant infections.
In my master’s research, I studied the effect of induced mutations on the pathogenicity index of avian influenza virus (H7N3), showing how in-ovo passaging can mimic field conditions and influence antigenic variation. These findings have implications for improving vaccine design and effectiveness. Additionally, I investigated the prevalence and antibiotic resistance patterns of Salmonella spp. in clinical samples from Pakistan, underscoring the need for cautious antibiotic use to prevent further resistance development.
My research interests lie at the intersection of immunology, microbiology, and vaccine development, with a strong commitment to advancing tools and knowledge that support both animal and public health.
Research interests
I am a scientist in the Animal Health Solutions team at AgResearch, New Zealand, with a strong background in microbiology and immunology. My research interests span host-pathogen interactions, microbial resistance, and vaccine development. During my PhD, I investigated the structural and functional roles of secretins—large outer membrane channels in Gram-negative bacteria—and revealed vulnerabilities that could be exploited to combat antibiotic-resistant infections. My master’s research focused on antigenic variation in avian influenza virus (H7N3), demonstrating how induced mutations affect pathogenicity and vaccine efficacy. I also studied the prevalence and antibiotic resistance patterns of Salmonella spp. in clinical samples. Currently, my work is focused on immunological strategies for methane mitigation, including epitope mapping, peptide design, and the development of flow cytometry and immune-capture technologies to study gut microbial interactions with the host immune system. Projects you're working on
My current research focus is to develop innovative tools to study the interaction of antibodies with the rumen methanogens with particular emphasis is on characterizing immunological epitopes of methanogen proteins to aid in the development of vaccine. I am also involved in developing methods using flow cytometry and immune-capture technology to study the gut microbes and their interactions with the host immune response. More than 12 years of experience in biochemistry, molecular biology, immunology and vaccine development. Current research is focused on development of recombinant methane vaccine. Discipline
Immunology – B-cells Molecular biology Host species
Cattle Small ruminants Pathogen
Bacteria Bacteria›E. coli Bacteria›Salmonella Viruses›Influenza virus Stage of vaccine development
Adjuvants Antigen discovery and immunogen design Correlates of protection – immunomonitoring Field trials Vaccine delivery