Teresa Freire, PhD in Biology (2003), is an associate professor of Immunology at the Immunobiology Departament of the School of Medicine (University of the Republic) in Montevideo, Uruguay. She is the group leader of the Immunomodulation and Vaccine development lab interested in investigating immune regulatory mechanisms induced by tumor cells and parasites, in particular triggered by carbohydrates. Another lab´s interest is the identification of molecules that mediate immunoregulation and the develpment of vaccines against fasciolosis or cancer. She has supervised 6 undergraduate theses, 9 M. Sc. theses and 2 Ph. D. theses. Nowadays her group is composed by master and PhD students and post-doctoral fellows.

(a) Education

1999: Biochemist, Facultad de Ciencias, Universidad de la República (School of Sciences, University of the Republic). “Characterization of Tn-expressing proteinas in ascitic samples from cancer patients”.

2003: PhD in Biology, Facultad de Ciencias, Universidad de la República (School of Sciences, University of the Republic). “Mucine-type glycosylation in helminth parasites”

(b) Professional employment

2008-Present: Associate Professor, Dept. Immunobiology, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay.

2007-2008: Post-doctoral Assistant Researcher, Immune Regulation and Vaccinology Unit, Insitut Pasteur, París, France. “DC-targeting of cancer-associated molecules expressing the Tn antigenndent manner. MALAMUD, M , CARASI, P , FREIRE, T., SERRADELL, M Biochemical and Biophysical Research Communications, v.: 495 1 , p.:1227 - 1232, 2017.

2006-2007: Post-doctoral Assistant Researcher, Immune Regulation and Vaccinology Unit  Insitut Pasteur, París, France. “Immunologcal properties of MUC6:Tn glycoproteins as anti-tumoral vaccines”.

2003-2005: Post-doctoral Assistant Researcher, Unité de Chimie Organique, Insitut Pasteur, París, France. “Enzymatic preparative synthesis of potential anti-tumoral vaccin glycoconjugates”.

(c) Representative publications of 5 last years

Immobilization of beta-galactosidase and alpha-mannosidase onto magnetic nanoparticles: A strategy for increasing the potentiality of valuable glycomic tools for glycosylation analysis and biological role determination of glycoconjugates Rodriguez E , K. FRANCIA , BROSSARD, N , Garcia Vallejo JJ , Kalay H , van Kooyk Y , FREIRE, T., Giacomini C Enzyme and Microbial Technology, v.: 117 p.:45 - 55, 2018

Heme-Oxygenase-1 Expression Contributes to the Immunoregulation Induced by Fasciola hepatica and Promotes Infection. CARASI, P , RODRIGUEZ, E , DA COSTA, V , FRIGERIO, S , BROSSARD, N. , NOYA, V , ROBELLO, C , ANEGóN, I , FREIRE, T. Frontiers in Immunology, v.: 8 p.:883 - 893, 2017

S-layer glycoprotein from Lactobacillus kefiri CIDCA 8348 enhances macrophages response to LPS in a Ca+2-depeFasciola hepatica Immune Regulates CD11c+ Cells by Interacting with the Macrophage Gal/GalNAc Lectin (Completo, 2017) RODRIGUEZ, E , CARASI, P , FRIGERIO, S , DA COSTA, V , VAN VLIET, S , NOYA, V , BROSSARD, N. , VAN KOOYK, Y , GARCíA-VALLEJO, J , FREIRE, T., Frontiers in Immunology, 2017 DOI: 10.3389/fimmu.2017.00264

Fasciola hepatica glycoconjugates immuneregulate dendritic cells through the Dendritic CellSpecific Intercellular adhesion molecule-3-Grabbing Non-integrin inducing T cell anergy. RODRIGUEZ, E , KALAY, H , NOYA, V , BROSSARD, N. , GIACOMINI, C. , VAN KOOYK, Y , GARCíA-VALLEJO, J , FREIRE, T., Scientific Reports, 7:46748. doi: 10.1038/srep46748, 2017

A mucin-like peptide from Fasciola hepatica instructs dendritic cells with parasite specific Th1polarizing activity. NOYA, V , BROSSARD, N. , RODRIGUEZ, E , DERGAN-DYLON S , CARMONA, C , RABINOVICH G , FREIRE, T., Scientific Reports, 7:40615. doi: 10.1038/srep40615 2017

Revisiting the human polypeptide GalNAc-T1 and T13 paralogs. FESTARI, F , TRAJTENBERG F , BEROIS, N , PANTANO S , REVOREDO L , KONG Y , SOLARISAQUIERES P , NARIMATSU Y , FREIRE, T., BAY, S , ROBELLO, C , BERNARD J , GERKEN TA , CLAUSEN H , OSINAGA, E Glycobiology (E), v.: 27 2017

Trypanosoma cruzi extracts elicit protective immune response against chemically induced colon and mammary cancers UBILLOS, L , FREIRE, T., BERRIEL, E , CHIRIBAO, ML , CHIALE, C. , FESTARI, MF , MEDEIROS, A , MAZAL, D , RONDAN, M , BOLLATI-FOGOLíN M , RABINOVICH, GA , ROBELLO, C , OSINAGA, E International journal of cancer. v.: 138 7 , p.:1719 - 1731, 2016

A mucin-like peptide from Fasciola hepatica induces parasite-specific Th1-type cell immunity NOYA, V , BROSSARD, N. , BERASAIN, P. , RODRIGUEZ, E , CHIALE, C. , MAZAL, D , CARMONA, C , FREIRE, T. Parasitology Research (E), v.: 115 3, p.:1053 - 1063, 2016

MUC5B silencing reduces chemo-resistance of MCF-7 breast tumor cells and impairs maturation of dendritic cells GARCíA, EP , TISCORNIA, I , LIBISCH, G , TRAJTENBERG, F , BOLLAT-FOGOLíN, M , RODRIGUEZ, E , NOYA, V , CHIALE, C. , BROSSARD, N. , ROBELLO, C , OSINAGA, E , FREIRE, T. International Journal of Oncology, v.: - 2016

Glycans from Fasciola hepatica Modulate the Host Immune Response and TLR-Induced Maturation of Dendritic Cells RODRIGUEZ, E , NOYA, V , CERVI, L. , CHIRIBAO, ML , BROSSARD, N. , CHIALE, C. , CARMONA, C , GIACOMINI, C. , FREIRE, T. PLoS Neglected Tropical Diseases, v.: 9 12, 2015

Mucin-like peptides from Echinococcus granulosus induce antitumor activity. NOYA, V , BAY, S , FESTARI, F , GARCIA, E , RODRIGUEZ, E , CHIALE, C. , GANNEAU, C , BALEUX, F , ASTRADA, S , BOLLATI-FOGOLIN, M , OSINAGA, E , FREIRE, T. International Journal of Oncology, v.: 43 3 , p.:775 - 784, 2013

(d) Supervisor of Master and Doctoral Thesis

Undergraduate Thesis: 6 concluded, 1 in course; M. Sc. Thesis: 9 concluded, 6 in course; Ph. D. Thesis: 2 concluded, 1 in course; Post-doctoral fellows: 2 concluded, 2 in course.