Otto Koekemoer

Dr
Otto
Koekemoer

Specialist Researcher Virology
Ondersteport Biological Products
Biography

I obtained a PhD in Biochemistry from the Potchefstroom University (NWU) in 2004 specialising in molecular virology. Most of mypostgraduate researched focussed on the molecular aspects of vaccine and diagnostic method development for several arboviruses of veterinary importance. I joined the Onderstepoort Veterinary Institute in 1996 and worked on the early development of molecular diagnostic assays for the identification and serotyping of African horsesickness viruses (AHSV), culminating in the first publication of a real-time RT-PCR test for the distinction of the nine AHSV serotypes, in 2008. My research group also published papers on the genetic characterisation of AHSV and the role of mutations and recombination in the evolution of the virus and its implications in vaccine development. I am currently employed as a specialist researcher in virology at Onderstepoort Biological Products where I am involved in several projects aiming to improve on and develop new viral vaccines.

Research interests

Orbivirus virology / vaccinology

New vaccine development

Adaptation of novel vaccine technology

Process development and optimisation

QC development

Clinical trials

Projects you're working on

Inactivated AHS vaccine development and testing

Bluetongue vaccine production process optimisation

Molecular QC tests used for QA

Discipline
Bio-manufacturing Challenge model development Challenge study design Clinical trials – efficacy Clinical trials – safety Formulation technology Immunology – B-cells Immunology – T-cells Immunology – innate Molecular biology QC test development Virology
Host species
Cattle Horses Small ruminants Zoonoses
Pathogen
Viruses VirusesAfrican horse sickness virus VirusesArboviruses VirusesBluetongue virus VirusesBovine ephemeral fever virus VirusesRift Valley fever virus
Stage of vaccine development
Adjuvants Clinical trials Correlates of protection – immunomonitoring Field trials Pre-clinical trials