Dr. Mohamed Elhadidy is currently a professor of Biomedical Sciences at Zewail City of science and technology, Egypt. Dr. Elhadidy holds a DVM degree from Mansoura University in Egypt. He obtained his master’s degree in 2006 in Microbiology from Mansoura University and obtained his PhD (2010) in Microbiology from Virginia Tech University, USA. From 2011-2017, Dr. Elhadidy served as a research scientist at School of Medicine, University of Saskatchewan, Canada; University of Bristol, UK; and University of Gent and Scientific Institute of Public health in Belgium. In 2018, he also served as a visiting professor at University of Bath, UK.
Dr. Elhadidy`s current research program aims to develop a better understanding of the ecology, evolution, and transmission of zoonotic bacterial diseases through the implementation of different population genetics and comparative genomic studies. I am particularly interested in the global health problem of antimicrobial resistance (AMR), using genomic epidemiology tools to understand the evolution and transmission dynamics of multidrug resistant pathogens including applying the input sequencing data into genome-wide association studies with biofilm formation (being a major contributor to AMR).
Dr. Elhadidy`s team are also implementing pan-genome reverse vaccinology as a robust post-genomic approach to screen and characterize potential vaccine candidates among wide range of pathogens, thus combating the increased threat of antimicrobial resistance and prevent the dissemination and emergence of multidrug-resistant pathogens in Egypt.
Another aspect of research conducted at Dr. Elhadidy`s lab is to apply the input sequencing data into genome-wide association studies to explore the association of different accessory genes and core-genome SNPs with biofilm formation (being a major virulence factor that contribute to antimicrobial resistance). Thereafter, the potential ability of several biocompatible nanoparticles loaded with compounds of natural origin are assessed for antibiofilm activity and for the transcriptional response of these gene expression patterns related to biofilm and virulence, including quorum sensing (QS) genes on treated bacteria with these organic compounds vs. untreated bacteria.
My current research program aims to develop a better understanding of the ecology, evolution, and transmission of zoonotic bacterial diseases through the implementation of different population genetics and comparative genomic studies. I am particularly interested in the global health problem of antimicrobial resistance (AMR), using genomic epidemiology tools to understand the evolution and transmission dynamics of multidrug resistant pathogens including applying the input sequencing data into genome-wide association studies with biofilm formation (being a major contributor to AMR).Furthermore, we are implementing pan-genome reverse vaccinology as a robust post-genomic approach to screen and characterize potential vaccine candidates among wide range of pathogens, thus combating the increased threat of antimicrobial resistance and prevent the dissemination and emergence of multidrug-resistant pathogens in Egypt.
1-Develop a better understanding of the pathogenesis, ecology, evolutional dynamics, and transmission of bacterial foodborne and zoonotic diseases through the implementation of different population genetics and comparative genomic studies of these bacterial pathogens.
2-Implementing pan-genome reverse vaccinology as a robust post-genomic approach to screen and characterize potential vaccine candidates among wide range of pathogens
3- Apply the input sequencing data into genome-wide association studies to explore the association of different accessory genes and core-genome SNPs with biofilm formation (being a major virulence factor that contribute to antimicrobial resistance). Thereafter, the potential ability of several biocompatible nanoparticles loaded with compounds of natural origin are assessed for antibiofilm activity and for the transcriptional response of these gene expression patterns related to biofilm and virulence, including quorum sensing (QS) genes on treated bacteria with these organic compounds vs. untreated bacteria.