Isabel de Miranda Santos

Professor
Isabel
de Miranda Santos

Associate Professor of Immunology
University of São Paulo
Email 
imsantos [at] fmrp.usp.br
Biography
I received an M.D. (1977) from the State University of Rio de Janeiro, Brazil, a master’s degree (1981) in Microbiology and Immunology from the Federal University of Rio de Janeiro and a Ph.D. (1992) in Internal Medicine (Immunology) from the University of São Paulo. I was a participant in the Biology of Parasitism course, Marine Biological Laboratory (1981). I was a fellow at the Gluck Equine Research Center, Lexington KY (1993) and ate the Harvard School of Public Health (1995-1997. My research has mostly focused on immunoparasitology and understanding mechanisms of parasitism and of immunopathology caused by parasites and how genetic variability of hosts affects outcomes of host-parasite interactions. I am especially interested in applying this knowledge to develop sustainable technologies to control tick infestations in cattle and dogs. My research also seeks to understand the mechanisms in the mammalian host that control pathogenesis of infections caused by Leishmania.
Research interests
Vaccinology, Immunoparasitology
Projects you're working on
Tick vaccines Correlates of resistance and susceptibility to tick infestations and to the Leishmaniases
Discipline
Challenge study design Clinical trials – efficacy Immunology – B-cells Immunology – T-cells Immunology – innate Parasitology
Host species
Cattle Dogs Zoonoses
Pathogen
BacteriaMycobacteria bovis Parasites ParasitesTicks ParasitesTrypanosoma
Stage of vaccine development
Antigen discovery and immunogen design Clinical trials Correlates of protection – immunomonitoring Pre-clinical trials