Myron Christodoulides

Professor
Myron
Christodoulides

Professor of Bacteriology
University of Southampton
Email 
mc4 [at] soton.ac.uk
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Biography
Myron Christodoulides is Professor of Bacteriology in the Faculty of Medicine, University of Southampton. His research interests are in developing vaccines for infectious diseases of humans and animals caused by bacterial and parasitic microorganisms. He also has interests in understanding host-pathogen interactions and in the development of rapid point-of-care diagnostic tests and novel antimicrobials. Current projects include vaccine development for swine and poultry dysentery, canine and human leishmaniasis and sexually transmitted diseases. Vaccine studies are making use of AI-driven antigen discovery and models of disease.
Research interests
Research interests are in 1) bacterial disease of humans and animals, such as leishmaniases, intestinal spirochaetoses, sexually transmitted diseases, sepsis, etc. 2) drug discovery for novel antimicrobials using synthetic chemistry, AI-directed library screening, 3) antimicrobial testing and AMR, 4) vaccine development, including recombinant proteins, chimera antigens, synthetic peptides, DNA/mRNA, reverse vaccinology 5) adjuvants, 6) diagnostic assay development, especially low cost rapid point-of-care lateral flow tests, 7) immunology of vaccine responses, 8) host cell-pathogen interactions, 9) in silico computational modelling of antimicrobials and vaccine antigens.
Projects you're working on
Current projects include 1) AI computational modelling of drugs for targeting enzymes of Brachyspira spp., 2) reverse vaccinology studies of Brachyspira spp., 3) vaccine development for N. gonorrhoeae and other pathogens on the WHO priority AMR list, 4) testing novel antimicrobial compounds derived from natural products and metal ions (silver, copper), 5) delivery systems for antimicrobials and antibiotics.
Discipline
Bacteriology Bioinformatics Cellular biology Immunology – B-cells Immunology – T-cells Immunology – innate Molecular biology Parasitology Protein biology Structural biology
Host species
Dogs Pigs Poultry Zoonoses
Pathogen
Bacteria Parasites
Stage of vaccine development
Adjuvants Antigen discovery and immunogen design Correlates of protection – immunomonitoring Vaccine delivery