Nigel Aminake Makoah

Dr
Nigel Aminake
Makoah

Senior Lecturer/Scientist
University of the Free State
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Biography
Dr. Nigel Aminake Makoah is a protein biochemist deeply dedicated to infectious diseases research. He obtained his MSc. in Biochemistry in 2006, establishing the foundation for a career marked by notable achievements. During his doctoral studies at the University of Wuerzburg, he made significant strides by assessing novel pharmacological compounds for dual activity against malaria and HIV while characterizing the malaria parasite's proteasome for potential therapeutic targets. Post-Ph.D., he received the prestigious Georg Forster Postdoctoral Fellowship to develop an antimalarial screening platform. Dr. Makoah furthered his impact at the University of Cape Town, evaluating drug candidates' pharmacokinetic properties and identifying drug targets for tuberculosis. Before joining the University where is currently affiliated, he worked as a senior scientist at the National Institute for Communicable Diseases in Johannesburg, where he developed a passion for designing antigens and antibodies for developing therapeutics. Currently, he is focusing on vital research involving native-like proteins of medically relevant viruses, including SARS-CoV-2, CCHFV, and CHIKV. Dr. Makoah's commitment to advancing diagnostics, prevention, and therapies against infectious pathogens showcases his dedication to public health and scientific progress.
Research interests
My research interests lie at the intersection of infectious disease epidemiology and immunology, with a particular focus on the development of effective vaccines and diagnostics for emerging and re-emerging infectious diseases. I am deeply invested in understanding the complex dynamics between pathogens and host immune responses, aiming to uncover novel therapeutic targets and vaccine candidates.
Discipline
Challenge study design Immunology – B-cells Molecular biology Protein biology Structural biology Virology
Host species
Zoonoses
Pathogen
Viruses VirusesArboviruses VirusesCoronavirus VirusesCrimean-Congo haemorrhagic fever virus VirusesEbolaviruses/filoviruses VirusesNairoviruses VirusesPeste des petits ruminants virus VirusesRift Valley fever virus