Amjad Ali

Dr
Amjad
Ali

Associate Professor
Atta-ur-Rahman School of Applied Biosciences, National University of Sciences & Technology
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Biography
I am heading the microbial- genomics and bioinformatics research (MGB) group interested in genomic epidemiology and comparative genomics to study the evolution and transmission of bacterial pathogens. We are particularly interested in the regional crisis of growing antimicrobial resistance and dissemination of multidrug resistant pathogens across species., also like to develop of tools, databases for pathogen genome analysis, prospective surveillance and tracking of emerging pathogens in the environment and clinical settings using whole genome sequencing and bioinformatics analysis. We are using comparative pangenome analysis and phylogenetics approaches to study the genome evolution, transmission, and resistance patterns in bacterial pathogens such as staphylococcus, pseudomonas, Klebsiella and Acinetobacter etc. We have developed high-throughput screening Tools/Software capable to analyses of microbial pangenome (big data) and therapeutic (vaccine/drugs) candidates’ identification, these include: 1. VacSol : 2. B-Vac 3, B-Vac-AI 4. PanRV : 5. Vacsol-ML(ESKAPE) :6. AbAMPdb: 7. rtAMPs: In the Structural Bioinformatics domain, we are employing the Homology structural modeling, Ab-initio modeling, Protein-protein interaction studies, Protein-Ligand interaction studies, Protein-nucleotide studies, Pharmacophore modeling, structural visualization of protein by using different tools
Research interests
Bioinformatics and Machining Leaning based prediction of protective antigen for vaccine design against poultry and animal infections.
Projects you're working on
1. Developed Tools for microbial genomics and vaccine designing 2. Working on multidomain epitope rich regions for potential vaccine development agains poultry diseases.
Discipline
Bacteriology Bioinformatics Immunology – B-cells Immunology – T-cells
Host species
Poultry Zoonoses
Pathogen
Bacteria BacteriaCorynebacterium BacteriaE. coli BacteriaSalmonella
Stage of vaccine development
Adjuvants Antigen discovery and immunogen design Clinical trials Commercialisation Pre-clinical trials