My research focus revolves around the bacterial Type VI Secretion System (T6SS), with a specific emphasis on Campylobacter jejuni. The T6SS has emerged as a critical mechanism in Gram-negative pathogens, and my research investigates its role in modulating microbial competition in the gut environment. I have conducted comprehensive experiments examining T6SS-mediated predation, assessing its impact on bacterial fitness, and elucidating the ecological consequences of T6SS activity under environmental stressors (Gupta et al., 2021; iScience; Gupta et al., 2022; STAR Protocol). Along with this I also have experience in generating live vector-based vaccines to substantially improve the antigen-specific local immune responses in the intestine along with significant immune protection against enteric colonization of C. jejuni in chickens, where we engineered a food-grade Lactic acid-producing bacteria, Lactococcus lactis (L. lactis) to express functionally active Surface Exposed Colonizing Protein (SECPs) of C. jejuni (Gorain et al., 2019, Vaccine). The Jejuni lipoprotein A (JlpA), one of the major surface colonizing proteins constitutively expressed and highly conserved among different Campylobacter spp, interacts with intestinal Heat-Shock Protein 90α (Hsp90α) and triggers pro-inflammatory responses, contributing to disease progression. Given its potential as a vaccine target against C. jejuni, we conducted experiments using chickens as a model to test the immune-protective efficacy of JlpA. Considering the gastrointestinal tract as the major site for C. jejuni colonization, we employed mucosal (intragastric) delivery of the JlpA antigen to disrupt pathogen transmission dynamics associated with persistent caecal colonization. The interdisciplinary nature of my research involves collaborating biological sciences with chemical sciences to investigate the role of Perovskite-based material in C. jejuni, Methicillin-resistant S. aureus biofilm degradation (Kandoth et al., 2023, ACS Nano). Moreover, I have expressed my expertise in cancer biology to check sub-cellular localization of Irridium conjugated compounds and reduction of the MCF7 proliferation (Das et al., 2023, Jn. of Med. Chem). Based on the above, I strongly believe that the synergy of technology and basic science will be perfect for unravelling my aptitude and research interests in multidisciplinary science. Eager to contribute to advancing knowledge in this field.