 
        Professor  
        Christian  
        Menge  
        
        Professor  
        Christian  
        Menge  
        head of Institute of Molecular Pathogenesis  
        Friedrich-Loeffler-Institute (FLI)/Federal Research Institute for Animal Health  
Biography
        As a licensed DVM, Prof. Menge possesses broad knowledge and expertise in surveillance, diagnosis, control and eradication of epizootic diseases in accordance with rules laid down in national and international animal health legislation. He has particular expertise in the analysis of bacterial host-interactions at the intestinal mucosal surface of livestock. Using in vitro culture systems and experimental infection studies in the target species his group elucidated the mechanisms by which enterohaemorrhagic Escherichia coli (EHEC) manipulates its host´s immune system. He also has substantial expertise in clinical immunology and the immunobiology of other bacterial pathogens, e.g., tuberculous and non-tuberculous Mycobacteria and Coxiella, viruses and parasites in large and companion animal species. His recent research focusses on drivers and dynamics of host-to-host and cross-species transmission of bacteria exhibiting antimicrobial resistance (AMR), also deploying innovative sampling strategies from a One Health perspective.  Research interests
        Developing and improving DIVA-compatible vaccines to protect livestock from bacterial diseases  and mitigate the carriage and shedding of zoonotic pathogens   Projects you're working on
        REPRODIVAC - Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact (https://www.reprodivac.eu/)  Discipline
        Bacteriology      Challenge model development      Immunology – T-cells      Immunology – innate  Host species
        Cattle      Small ruminants      Zoonoses  Pathogen
        Bacteria›Chlamydophila      Bacteria›E. coli      Bacteria›Mycobacteria bovis      Bacteria›Mycoplasma      Bacteria›Salmonella  Stage of vaccine development
        Antigen discovery and immunogen design      Correlates of protection – immunomonitoring      Pre-clinical trials