
Professor
Christian
Menge
Professor
Christian
Menge
head of Institute of Molecular Pathogenesis
Friedrich-Loeffler-Institute (FLI)/Federal Research Institute for Animal Health
Biography
As a licensed DVM, Prof. Menge possesses broad knowledge and expertise in surveillance, diagnosis, control and eradication of epizootic diseases in accordance with rules laid down in national and international animal health legislation. He has particular expertise in the analysis of bacterial host-interactions at the intestinal mucosal surface of livestock. Using in vitro culture systems and experimental infection studies in the target species his group elucidated the mechanisms by which enterohaemorrhagic Escherichia coli (EHEC) manipulates its host´s immune system. He also has substantial expertise in clinical immunology and the immunobiology of other bacterial pathogens, e.g., tuberculous and non-tuberculous Mycobacteria and Coxiella, viruses and parasites in large and companion animal species. His recent research focusses on drivers and dynamics of host-to-host and cross-species transmission of bacteria exhibiting antimicrobial resistance (AMR), also deploying innovative sampling strategies from a One Health perspective. Research interests
Developing and improving DIVA-compatible vaccines to protect livestock from bacterial diseases and mitigate the carriage and shedding of zoonotic pathogens Projects you're working on
REPRODIVAC - Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact (https://www.reprodivac.eu/) Discipline
Bacteriology Challenge model development Immunology – T-cells Immunology – innate Host species
Cattle Small ruminants Zoonoses Pathogen
Bacteria›Chlamydophila Bacteria›E. coli Bacteria›Mycobacteria bovis Bacteria›Mycoplasma Bacteria›Salmonella Stage of vaccine development
Antigen discovery and immunogen design Correlates of protection – immunomonitoring Pre-clinical trials