Dr
Dr.Shruti
Pyasi
Dr
Dr.Shruti
Pyasi
Research Associate
Post-Graduate Institute of Veterinary Education & Research (PGIVER), Jaipur
Biography
I completed my Ph.D. in Biosciences & Biomedical Engineering at IIT Indore in 2022, focusing on Seroepidemiology, molecular characterization, and prophylactic approaches against Bovine Ephemeral Fever Virus (BEFV).
Key publications from my research include:
1. Finding potential inhibitors against RNA-dependent RNA polymerase of BEFV: an in-silico study – Journal of Biomolecular Structure and Dynamics (2021).
2. Complete genome sequencing and mutation-associated protein dynamics of the first Indian BEFV isolate (2021).
3. Identification and phylogenetic characterization of BEFV of Middle Eastern lineage from 2018–2019 outbreaks in India (2020).
4. Immunoinformatics design of a multi-epitope subunit vaccine against BEFV (2021).
5. Rescue of BEFV through reverse genetics and challenges in propagation (2024).
My expertise spans molecular virology, functional genomics, genetic engineering, and bioinformatics, with a focus on emerging and zoonotic viral diseases.
Research interests
Molecular virology and One Health, with a focus on emerging and re-emerging veterinary and zoonotic viruses. Key areas include molecular characterization and evolution of RNA viruses that includes Bovine Ephemeral Fever Virus (BEFV), Canine Distemper Virus (CDV), and Canine Parvovirus (CPV)) and a DNA virus, such as Lumpy Skin Disease Virus (LSDV). Exploring their viral replication mechanisms and antiviral target discovery, host–pathogen interactions and genomics-driven pathogen surveillance. I integrate molecular biology, structural bioinformatics, and multi-omics approaches to develop improved diagnostics, vaccines, and therapeutics. Projects you're working on
I am mainly working on five major zoonotic diseases viz. Brucellosis, Tuberculosis, Paratuberculosis, salmonellosis, and rabies. Here, work also done on certain viruses like Lumpy skin disease virus, Canine Parvovirus, Caine distemper virus. Conducting active and passive surveillance of high-priority zoonotic pathogens affecting livestock and companion animals.
Integrating molecular diagnostics (PCR, RT-PCR, LAMP) with field epidemiology to detect and characterize circulating strains. Discipline
Bacteriology Bioinformatics Epidemiology Immunology – B-cells Immunology – T-cells Immunology – innate Molecular biology Parasitology Virology Host species
Buffalo Camels Cats Cattle Dogs Small ruminants Zoonoses Pathogen
Bacteria Bacteria›Brucella Bacteria›Leptospira Bacteria›Mycobacteria bovis Bacteria›Salmonella Parasites›Babesia Viruses Viruses›Bovine ephemeral fever virus Viruses›Bovine viral diarrhoea Viruses›Calicivirus Viruses›Capripoxvirus Viruses›Parvovirus Stage of vaccine development
Adjuvants Antigen discovery and immunogen design