Lindert Benedictus

Dr
Lindert
Benedictus

Assistant Professor in farm animal immunology and infection biology
Farm Animal Health, Department Population Health Science, Faculty of Veterinary Medicine, Utrecht University, the Netherlands
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Biography

Lindert is an assistant professor in farm animal immunology and infection biology at the division of Farm Animal Health of the Faculty of Veterinary Medicine at Utrecht University. His research focuses on bovine immunology and infection biology and he also teaches in the Veterinary bachelors and masters curriculum. Lindert studied Veterinary Medicine at Utrecht University and received his Doctorate in Veterinary Medicine, with a specialization in Farm Animal Health, in 2012. Immediately thereafter, Lindert started his PhD studies into “Bovine materno-fetal alloimmune mediated disorders” under supervision of Dr. A.P. Koets, Prof. Dr. V.P.M.G. Rutten and Prof. Dr. M. Nielen at the division of Immunology, Faculty of Veterinary Medicine, Utrecht University, and defended his thesis in 2015. For his first post-doctoral position Lindert worked at the department of Medical Microbiology (University Medical Centre, Utrecht) as well as continuing to work at the division of Immunology. He participated in a project to develop innovative new vaccination strategies against Staphylococcus aureus mastitis in dairy cattle, investigating host-pathogen interactions as well as performing experimental vaccine trials. Next, he moved to Scotland working as a research fellow at the Roslin Institute (University of Edinburgh), studying the role of non-conventional T-cells and antigens as novel vaccine targets for bovine tuberculosis, a collaborative project between the Roslin institute and APHA working with Dr. T. Connelley, Prof. Dr. M. Vordermeier and Prof. Dr. I. Morrison. A major result of this PostDoc was the first functional characterization of MAIT cells in cattle.

https://www.researchgate.net/profile/Lindert_Benedictus; https://twitter.com/DrBenedictus/; https://orcid.org/0000-0001-7605-2710

Research interests

Farm animal Immunology, Infection Biology and Vaccinology, with a focus on ruminants. Particularly interested in mastitis, S. aureus, vaccines, MAIT cells, reproductive immunology. 

Projects you're working on

CANVAS - "Broadly protective glycoconjugate vaccines targeting major animal and zoonotic Gram-positive pathogens". This project aims for proof-of-concept that conserved cell wall polysaccharides can be used as targets for broadly protective glycoconjugate vaccines against the bacterial species Streptococcus suis and Staphylococcus aureus, important zoonotic pathogens in pigs and cattle, respectively. https://www.health-holland.com/project/2019/complex-bacterial-sugars-as-novel-vaccine-targets

Staphylococcus aureus infection dynamics in cattle - Characterizing the contribution of colonisation of cattle with S. aureus to the spread of S. aureus and to the occurrence of intramammary infections and determine how colonisation shapes the adaptive immune response against S. aureus.

Mucosal-associated invariant T cells in Cattle - https://t.co/vMbaerIiTs?amp=1

Discipline
Bacteriology Immunology – B-cells Immunology – T-cells Immunology – innate
Host species
Cattle Pigs Small ruminants Zoonoses
Pathogen
Bacteria BacteriaMycobacteria bovis
Stage of vaccine development
Antigen discovery and immunogen design Correlates of protection – immunomonitoring