Angela Makumi

Dr
Angela
Makumi

Post Doctoral Fellow
International Livestock Research Institute-Nairobi Kenya
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Biography

I have an Msc. In Molecular Biology and a PhD in Bioscience Engineering from Vrije Universiteit Brussles and the latter from KU Leuven Belgium. During this time, I developed a passion for bacteriophage(phage) research and the general applications of phages. To further understand this intricate interplay between phages and their host (bacteria), my PhD thesis project was focused on impact of phages on the ecological fitness and eradication of multidrug resistant invasive non-typhoidal Salmonella enterica from Sub-Saharan Africa.. During my PhD research,  I hacquired expertise in state-of-the-art genetics used to further study interesting phage-host interactions. I also studied the infection dynamics of bacteriophage  BTP1 (a predominant novel phage isolated from the invasive non-typhoidal salmonella strains) on Salmonella Typhimurium at single-cell level together with the specific expression of phage encoded genes. To further expound my knowledge on the role of phages in different industrial sectors, I extended my research career as a junior post- doctoral fellow to study phages infecting lactic acid bacteria at University College Cork (UCC-Ireland). Having acquired vast technical experience in phage research as well as its advantages and its limitations, I am currently a post-doctoral fellow at the International Livestock Research Institute( Nairobi-Kenya) providing my technical expertise in the field of antimicrobial resistance and how phages could be used as a potential alternative to control the growing problem of antimicrobial resistance in poultry farming. 

Research interests

My research interests are genomics, synthetic engineering ( in phages),molecular biology, animal models and vaccines as an intervention strategy to address broad range of issues related to Salmonella whether host restricted or zoonotic. 

Projects you're working on

Use of bacteriophages (bacterial viruses) as a One Health approach for the replacement of antibiotics, and reduction of drug-resistant nontyphoidal Salmonella, in poultry farms in Kenya

Discipline
Bacteriology Molecular biology Virology
Host species
Poultry
Pathogen
BacteriaSalmonella
Stage of vaccine development
Antigen discovery and immunogen design