Title: Phenotypic and Molecular Characterization of Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli and Klebsiella pneumoniae Isolates from Humans and Livestock in Western Uganda. Description: This project investigates the prevalence, resistance profiles, and genetic determinants of ESBL-producing E. coli and K. pneumoniae isolated from human and livestock sources in selected communities of Western Uganda. The study applies both phenotypic methods (culture and antibiotic susceptibility testing) and molecular techniques (PCR amplification of bla genes and sequencing) to characterize isolates. The goal is to understand the potential cross-transmission of resistant strains between humans and animals, identify high-risk reservoirs, and provide data to support local antimicrobial stewardship and One Health policies.