Maruping Mangena

Dr
Maruping
Mangena

Researcher
Agricultural Research Council-Onderstepoort Veterinary Research ARC-OVR)
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Biography
I am a dedicated and highly driven developing researcher, with a boundless interest in science, but I am mostly fascinated by the (micro) biological world and the genetics that underlies it. I am more interested in the application of the knowledge I acquired during my studies/training. I embrace research environments I am unacquainted with, and learning of new concepts. This is attested to by my undertaking of three-isolated post-graduate research fields; my Honors Degree was in Human Physiology and my Master’s Degree was in Biochemistry, specializing in Molecular Biology. I have recently completed Doctoral (PhD) degree at the Faculty of Science at the University of Pretoria. The project was based on Molecular Diagnostics where I was investigating the prevalence of Q-fever and toxoplasmosis in slaughter animals in Gauteng red meat abattoirs and also development of cell-mediated immunity response biomarkers. With this project, we managed to optimize and introduce diagnostic PCR testing of Q fever at the Bacterial PCR Laboratory –ARC-OVR. Currently I am currently involved in Food and Mouth Disease (FMD) at ARC-OVR Transboundary Animal Programme (TADP). The projects I am involved in include construction of FMDV -specific phage-display libraries for epitope identification to be used in improved design of FMD vaccine. I am also involved in the multi-scale infection dynamics from cells to landscapes: FMD in African buffalo as well as FMD Biobank projects respectively.
Research interests
I have interest in Foot Mouth Disease Virus (FMDV), Q fever, toxoplasmosis and Neosporosis. The research molecular detection, vaccine and potential vaccine development. I also have in interest in Brucella research and molecular Biology.
Projects you're working on
I am currently working on the following projects: Improvement of Foot-and-Mouth Disease Virus SAT-specific phage display immune libraries & characterization of cattle and buffalo-derived scFvs, Multi-scale infection dynamics from cells to landscapes: FMD in African buffalo, Global Q fever survey and a Survey on prevalence of brucellosis in South Africa
Discipline
Bacteriology Immunology – T-cells Molecular biology Virology
Host species
Buffalo Cattle Small ruminants Wildlife Zoonoses
Pathogen
Bacteria BacteriaBrucella VirusesFoot-and-mouth disease virus