Tom McNeilly

Dr
Tom
McNeilly

Director of Research and Innovation, Head of Disease Control Department
Moredun Research Institute
Biography

Dr Tom McNeilly, a qualified veterinary surgeon, is an immunologist and infectious disease biologist with expertise in translational aspects of ruminant immunology, including vaccine development and population-based studies on immune variation in livestock species. He has been involved in the development vaccines to control parasitic, viral and bacterial infections in both cattle and sheep, including those which have progressed to field evaluation. His work has used advanced surgical and culture-based methods in ruminant species to define key host-pathogen interactions at the mucosal interface and has identified several heritable immune biomarkers in ruminants associated with increased resistance to disease. He has published over 100 refereed publications in international peer-reviewed journals.

  His current interests are: 1. The use of in vivo and in vitro study systems to understand host-pathogen interactions at mucosal surfaces; 2. The development of vaccines against major endemic pathogens of sheep and cattle, including gastro-intestinal parasites and the ruminant Hazard Group 3 pathogens Coxiella burnetii and Shiga-toxin producing Escherichia coli (STEC); 3. The epidemiology of these pathogens in terms of optimal vaccine deployment and/or assessment of zoonotic risk; 4. The causes and consequences of immune variation in in ruminant populations including trade-offs between productivity and immune function.

Research interests

Translational livestock immunology; Sheep and cattle vaccine development; Causes and consequences of immune variation in livestock

Projects you're working on

2023-2026       BBSRC (BB/X006743/1): Defining the in vivo physiology of E. coli O157:H7 in cattle to improve phage-based interventions.

2023-2026       BBSRC ICRAD (BB/X020142/1): Q-Net-Assess (Improved molecular surveillance and assessment of host adaptation and virulence of Coxiella burnetii in Europe).

2022-2027       Scottish Government Strategic Research Programme: Ruminant nematode vaccine development; Ruminant organoid models of disease; STEC in farmed deer; Use of medicine use records to optimise livestock production.

2022-2027       EU Horizon Europe: REPRODIVAC – Next-generation vaccines and diagnostics to prevent livestock reproductive diseases of worldwide impact.

2020-2023       EBRC/Zoetis: Ostertagia ostertagi in cattle: Understanding host-parasite-drug interactions in different developmental stages.

2019-2024       NERC LARGE grant (NE/R01664X/1): The ecology within: The impact of gut ecosystem dynamics on host fitness in the wild.

2018-2023       Wellcome Trust Collaborative Awards in Science. Tuft cell activation and intestinal immunity.

Discipline
Bacteriology Immunology – B-cells Immunology – T-cells Immunology – innate Parasitology
Host species
Cattle Small ruminants Wildlife Zoonoses
Pathogen
BacteriaE. coli Parasites ParasitesNematodes
Stage of vaccine development
Adjuvants Antigen discovery and immunogen design Clinical trials Correlates of protection – immunomonitoring Field trials