Myself and my lab membershave developed dietary supplements to enhance the immunity in aquatic organisms against several pathogenic bacterial diseases in aqua farming. Various nanocomposites were formulated using extracts of medicinal plants, extracts of seaweeds and animal proteins that enhance the immunity of the organisms and improve the outcome of aqua industry. The formulated substances play a vital role in enhancing immunity, improving stress tolerance and disease resistance in aquatic animals which would help to achieve high yield in aqua farming. The functions of the crustacean immune genes reported in mywork could be used to enhance the immune system of crustaceans and prevent the spread of disease in commercially important cultured crustaceans. Thus, my contribution provides solutions to improve the economic status of aqua industry through a less toxic, low cost and eco-friendly approach. Moreover, now we are concentrating in the development of vaccines against Aeromonas infection in Indian aquaculture in the project entitled “Production of novel vaccines for the prevention of Aeromonas and Vibrio infection in finfish culture”. We have inactivated two aquaculture predominant pathogens (Aeromonas and Vibrio) in our laboratory and further done encapsulation and immersion experimentation for infected Indian major carps to protect from concern diseases. The outcome of the experiment provides positive results which motivates us to proceed further. Hence, we are in the initial stage of developing inactivated vaccines against Aeromonas and Vibrio infection.