A novel mRNA-based multiepitope vaccine candidate against Cryptosporidium hominis and Cryptosporidium parvum employing reverse-vaccinology and immunoinformatics approaches.

The parasite Cryptosporidium spp. causes cryptosporidiosis, a diarrheal disease in humans and animals. This study describes the development of mRNA vaccine targeting antigens from C. hominis and C. parvum, important gut pathogens. This vaccine was designed with reverse vaccinology and immunoinformatics as no FDA-approved vaccine exists for cryptosporidiosis.